Synthesis of a Non-Hydrolyzable Dinucleoside Analogue
نویسندگان
چکیده
منابع مشابه
T4 RNA ligase catalyzes the synthesis of dinucleoside polyphosphates.
T4 RNA ligase has been shown to synthesize nucleoside and dinucleoside 5'-polyphosphates by displacement of the AMP from the E-AMP complex with polyphosphates and nucleoside diphosphates and triphosphates. Displacement of the AMP by tripolyphosphate (P3) was concentration dependent, as measured by SDS/PAGE. When the enzyme was incubated in the presence of 0.02 mm [alpha-32P] ATP, synthesis of l...
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ژورنال
عنوان ژورنال: Nucleosides and Nucleotides
سال: 1991
ISSN: 0732-8311
DOI: 10.1080/07328319108046677